Volume 5, Issue 5

May 2018

Combined Photothermal Therapy and Immunotherapy: Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy (Adv. Sci. 5/2018)

Jinrong Peng Yao Xiao Wenting Li Qian Yang Liwei Tan Yanpeng Jia Ying Qu Zhiyong Qian

1870031 First Published: 15 May 2018

Reinvigorating the tumor infiltrating lymphocytes (TILs) is critical for tumor immunotherapy, and photothermal therapy (PTT) and regulation of tumor cell metabolism are effective strategies for TIL reinvigoration. In article number 1700891, Zhiyong Qian and coworkers develop a combination strategy composed of photosensitizer micelle mediated PTT and indoleamine 2,3dioxygenase (IDO) inhibitor induced IDO activity inhibition for enhanced tumor PTT and immunotherapy.